The Center for Chronic Disease Research and Policy hosted the Mt Hood Diabetes Challenge June 23-25, 2025 at the Chicago Theological Seminary. The international health economics and diabetes simulation modeling conference began with a workshop taught by Philip Clarke, Professor of Health Economics and Director of the Health Economics Research Centre at Oxford University, who has served as Mt Hood’s chair since 2010. Fifty-nine researchers from around the world participated in the challenges, talks, and abstract sessions. With a special focus on weight reduction, the conference expanded beyond diabetes to pose additional challenges on osteoarthritis and smoking. Plenary lectures were given by UChicago’s Eric Polley and Jonathan Ozik, as well as virtually by Talitha Feenstra of Rijksuniversiteit Gronigen.